I think a lot of people over complicate things. I just set mine up per Bill's nickel height guidelines, achieved output balance between pups and rocked out. Haven't touched them since.

Granted, my 280's are in a non traditional Strat and I'm not trying to get traditional tones.

I don't adjust my amp EQ for any of my guitars. I have a universal setting and let the guitar's characteristics take care of the rest.
--Garrett--